Nanomaterials as carriers to improve the photodynamic antibacterial therapy

Liu, Houhe and Jiang, Yuan and Wang, Zhen and Zhao, Linping and Yin, Qianqian and Liu, Min (2022) Nanomaterials as carriers to improve the photodynamic antibacterial therapy. Frontiers in Chemistry, 10. ISSN 2296-2646

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Abstract

The main treatment for bacterial infections is antibiotic therapy, but the emergence of bacterial resistance has severely limited the efficacy of antibiotics. Therefore, another effective means of treating bacterial infections is needed to alleviate the therapeutic pressure caused by antibiotic resistance. Photodynamic antibacterial therapy (PDAT) has gradually entered people’s field of vision as an infection treatment method that does not depend on antibiotics. PDAT induces photosensitizers (PS) to produce reactive oxygen species (ROS) under light irradiation, and kills bacteria by destroying biological macromolecules at bacterial infection sites. In recent years, researchers have found that some nanomaterials delivering PS can improve PDAT through targeted delivery or synergistic therapeutic effect. Therefore, in this article, we will review the recent applications of several nanomaterials in PDAT, including metal nanoclusters, metal-organic frameworks, and other organic/inorganic nanoparticles, and discuss the advantages and disadvantage of these nanomaterials as carriers for delivery PS to further advance the development of PDAT.

Item Type: Article
Subjects: European Repository > Chemical Science
Depositing User: Managing Editor
Date Deposited: 10 Mar 2023 12:42
Last Modified: 16 Sep 2023 04:04
URI: http://go7publish.com/id/eprint/1021

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