Snider, Daltry L. and Horner, Stacy M. (2021) RNA modification of an RNA modifier prevents self-RNA sensing. PLOS Biology, 19 (7). e3001342. ISSN 1545-7885
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Official URL: https://doi.org/10.1371/journal.pbio.3001342
Abstract
A new study in PLOS Biology finds that interferon (IFN)-induced adenosine deaminase acting on RNA 1 (ADAR1) mRNA is N6-methyladenosine (m6A) modified to promote its translation, enabling ADAR1 to modify self-double-stranded RNAs (dsRNAs) generated during the IFN response and preventing activation of the melanoma differentiation–associated protein 5 (MDA5)-mediated host antiviral response.
| Item Type: | Article |
|---|---|
| Subjects: | European Repository > Biological Science |
| Depositing User: | Managing Editor |
| Date Deposited: | 20 Feb 2023 05:22 |
| Last Modified: | 05 Jun 2024 09:24 |
| URI: | http://go7publish.com/id/eprint/1062 |
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