Enterobacteriaceae Therapy using Bacteriophages: A Review

Udomessien, C. K. and Okon, N. E. and Ubah, C. B. and Oti, V. B. and Ioannou, M. and Ufot, E. A. (2022) Enterobacteriaceae Therapy using Bacteriophages: A Review. Journal of Pharmaceutical Research International, 34 (43A). pp. 14-23. ISSN 2456-9119

[thumbnail of 6410-Article Text-8677-1-10-20221006.pdf] Text
6410-Article Text-8677-1-10-20221006.pdf - Published Version

Download (324kB)

Abstract

Enterobacteriaceae are a family of bacteria, including many familiar pathogens that cause signs of diarrhoea in humans and animals, such as Escherichia coli, Salmonella, Shigella, and Klebsiella. Enterobacteriaceae, the first Gram-negative bacteria, are bacilli (rod-shaped) facultative anaerobes. They ferment sugars to produce lactic acid and other end products. They are usually about 1-5 μm in length. Most are motile because of many flagella; however, a few genera are non-motile. They do not form spores. Most Enterobacteriaceae members have fimbriae necessary for the adhesion of the bacterial cells to their hosts. They are economically significant and thus a considerable concern because they cause the deaths of millions of people each year, resulting in a significant situation to curb their infection. Due to the emergence of drug-resistant bacteria, there is an urgency to search for replacement therapies against bacteria in the Enterobacteriaceae family. To find a solution to this traumatic problem, studies have been launched in the areas of bacteriophages and their therapeutic application as a significant replacement for antibiotics. Bacteriophage therapy utilizes a different mechanism in destroying bacteria; hence, it is a better alternative to antibiotics. This review sheds light on Enterobacteriaceae and bacteriophage therapy, as well as the history of bacteriophage therapy, its mode of lysing bacteria and formulations of phages.

Item Type: Article
Subjects: European Repository > Medical Science
Depositing User: Managing Editor
Date Deposited: 14 Mar 2023 07:21
Last Modified: 06 Feb 2024 03:51
URI: http://go7publish.com/id/eprint/1621

Actions (login required)

View Item
View Item