Asymmetric Dimethyl Arginine Level in Children with Sickle Cell Disease: A Cross Sectional Study

Elhawary, Eslam and El-Shanshory, Mohamed Ramadan and Nagy, Hala Mohamed and Bradaey, Mohamed Hosny El and Khedr, Seham Fathy (2021) Asymmetric Dimethyl Arginine Level in Children with Sickle Cell Disease: A Cross Sectional Study. Journal of Advances in Medicine and Medical Research, 33 (18). pp. 93-98. ISSN 2456-8899

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Abstract

Background: Sickle cell disease (SCD) consists of a group of hemoglobinopathies in which individuals inherit hemoglobin variants derived from single point mutations. Asymmetric dimethylarginine (ADMA) contributes to limiting Nitric Oxide (NO) bioavailability in SCD. The aim of the present study was to assess the level of the Asymmetric Dimethyl Arginine in children with sickle cell.Methods: This cohort cross-sectional study wascarried out on 60 children which were divided in to 3 equal groups. Group I: SCD children with sickle retinopathy. Group II: SCD children without retinopathy. Group III: healthy control children who were selected from the outpatient clinic. Results: There was a significant increase in ADMA level among participants withSCD. There was a positive significant correlation between ADMA level and family history as well as the incidence of hepatomegaly. There was no significant correlation between ADMA level and demographic and laboratory parameters except LDH.Conclusions: The level of ADMA is elevated in children with sickle cell anemia. High plasma ADMA level is a risk for hepatomegaly in children with sickle cell anemia.

Item Type: Article
Uncontrolled Keywords: Asymmetric dimethyl arginine; ADMA; sickle cell disease; SCD
Subjects: European Repository > Medical Science
Depositing User: Managing Editor
Date Deposited: 03 Mar 2023 04:57
Last Modified: 30 Dec 2023 13:07
URI: http://go7publish.com/id/eprint/169

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