Synthesis and Stability Studies of 225 Actinium Tin Colloid Radiopharmaceutical

Synthesis of novel 225Ac-Sn particles was described for the first time. Detailed experimental and stability studies were successfully exhibited. Treatment of excess amount of SnCl2 with 0.2 mCi 225 Ac furnished highly stable 225 Ac tin colloid with 90% of radiochemical yield (RCY) at optimized reaction condition. R-TLC analyses indicated 95% of radiochemical purity (RCP). Stability studies showed that colloidal structure also retained free daughter radionuclides formed by the 225 Ac decay chain. 225 Ac tin colloids could be ideal nanocarriers for localized cell killing due to high linear energy transfer and prevention of free radioisotope daughters.