The Effect of Ellagic Acid and Sodium Fluoride Intake on Total Sialic Acid Levels and Total Oxidant/Antioxidant Status in Mouse Testicular Tissue

Aims: In the present study was aimed to investigate the levels of Total Oxidant Status (TOS), Total Antioxidant Status (TAS) and Total Sialic Acid (TSA) in the testis of mice treated with sodium fluoride (NaF) and ellagic acid (EA).

Methodology: Forty Swiss albino mice were randomized into 5 equal groups for 4 weeks as follows: Group I (control) received standart chow diet and drinking water. Group II, III, IV and V treated with subcutaneously 0.02% dimethylsulfoxide (DMSO) and 10 mg/kg/day EA in DMSO solution and 150 ppm/mouse/day NaF in drinking water and NaF plus EA, respectively. The levels of TOS, TAS and TSA were analyzed in the testis tissue by using spectrophotometric methods.

Results: EA treatment decreased levels of TOS and TSA during NaF uptake significantly. It was found to not create an important change on TAS levels of NaF received mice.

Conclusions: It was concluded that EA may be protective on testicular oxidative stress caused of fluoride.