Antimicrobial, Analgesic and Anti-inflammatory Activity of Some Synthesized Quinazoline Derivatives

Series of 7-chloro-3-[substituted (amino/phenyl amino)]-2-phenyl quinazolin-4(3H)-one/thione derivatives and 1-(7-chloro-4-oxo/-2-phenylquinazoline-3 (4H-yl)) substituted urea derivatives were synthesized and characterised The reaction proceeds through the intermediate 7-chloro-2-phenyl-4H-benzo[d] [1, 3] oxazin-4-one. Synthesized compounds were characterised from infrared (IR), 1H nuclear magnetic resonance (NMR) and mass spectra (m/z) and elemental analysis. By using the agar diffusion cup plate method, tail immersion method, and carrageenan-induced paw oedema method, respectively, the antibacterial, analgesic, and anti-inflammatory efficacy was examined. Based on the screening data of the new quinazoline derivatives, five compounds are found to be effective with antimicrobial activity. Five compounds exhibited good analgesic and anti-inflammatory activity.