IN VITRO EFFECTS OF ALBENDAZOLE ON THE HISTOLOGY AND HISTOCHEMISTRY OF TRICHURIS GLOBULOSA (NEMATODA), A PARASITE OF SHEEP AND GOAT

In the present study and attempt has been made to observe the in vitro effect of albendazole (ABZ), an anthelmintic drug, on the histology and histochemistry of Trichuris globulosa. The parasites were incubated in different working concentrations of the drug ranging from 50-200 ppm. Histologically the body wall and intestine of the treated worms were most effected by ABZ. No prominent effect of ABZ was observed on the reproductive parts, however, swelling of the polar plugs was observed in treated worms. Lipids (general lipids, neutral and acidic lipids, phospholipids and neutral fats) and carbohydrates (glycogen and acid mucopolysaccharides) were observed in lesser concentration in body wall, intestine and reproductive parts of treated worms. Increased concentration of phospholipids in intestinal epithelium, increased concentration of glycogen and acid mucopolysaccharides in developing oogonia and oocytes was detected in treated worms.