An Advanced Study on Electrochemical Behavior of Chalcone at a Glassy Carbon Electrode and Its Analytical Applications

A simple and rapid method was developed using cyclic, differential pulse and square wave voltammetric techniques for the determination of trace-level chalcone at a glassy carbon electrode. Chalcone could produce two anodic peaks at about 0.514 V and 1.478 V and a cathodic peak at about ?0.689 V. The differential pulse voltammerty presents a good linear response as compared to square wave voltammetry in the range of 0.2 - 10 ?M with a detection limit of 0.18 ?M. The proposed method was used successfully for its quantitative determination in spiked human plasma and urine as real samples. The proposed method offered the advantages of accuracy and time saving as well as simplicity of reagents and apparatus. In addition, the results obtained in the analysis of chalcone in spiked human plasma and urine samples demonstrated the applicability of the method for real sample analysis.