Synthesis and Antibacterial Potency of Some 3-methyl-2-oxo-1,2-dihydroquinoxaline-6- sulfonohydrazone Derivatives

Studies on the synthesis of some sulfa quinoxaline has generate a considerable reputation as a result of their outstanding biochemical properties. This recent study was designed to prepared some sulfa quinoxaline hydrazone derivatives and studying their antimicrobial potency. The 3-methyl-2-oxo-1,2-dihydroquinoxaline-6-sulfonohydrazone derivatives were synthesized by the reactions of 3-methyl-2-oxo-1,2-dihydroquinoxaline-6-sulfonohydrazide and six substituted benzaldehydes and examined for their possible antibacterial potency. The synthetic compounds exhibited wide-ranging spectrum action counter to twenty-four bacteria strains with minimum inhibitory concentrations values 0.0313 - 0. 250 mg/mL. This is a suggestion that such compounds could be used to formulate antibiotics to circumvent the problem of increasing resistance by pathogens to the existing synthetic antibiotics.