One Pot Synthesis Routes for Biologically Active Pyrazoles

Present work deals with the preparation of some Pyrazole derivative salts which was prepared by using different kinds of aldehydes and hydrazine derivatives by using alkoxide as a base and using the 1, 3- dicarbonyl compound like ethyl acetoacetate at room temperature. Pyrazole containing molecules possess a wide range of biological activities such asantibacterial, antifungal, antiviral, anticancer, antidiabetic, anti-inflammatory, estrogen receptor agonists, etc. In recent years one pot three component synthesis has been taken a greater importance as it synthesize the most important pyrazole and its different kinds of derivative in just a single step. The reaction mixture was stirred on magnetic stirrer for about 10 to 20 minutes till colour change is observed and then product is separated by using organic solvents. The product obtained was converted to sodium salt ofPyrazole derivative by base hydrolysis. The entire synthesized compound was tested for their antibacterial activity against the Gram-positive and Gram-negative strains of bacteria. Amongst all synthesized compounds sodium 3-(3,4-dimethoxyphenyl)-5-methyl-1-phenyl-1H-pyrazole-4-carboxylate were found to be more potent as antibacterial Staphylococcus aureus and Bacillus subtilisagents. Whereas compound sodium 5-methyl-3-(3-nitrophenyl)-1H-pyrazole-4-carboxylate was more active against antibacterial Escherichia coli and Proteus vulgaris as antibacterial agent. The investigation of antibacterial screening data revealed that most of the tested compounds showed moderate to good antibacterialactivity.