Assessment of the Changes in the Salivary Profile and its Clinical Correlation in Leukemic Children Undergoing Chemotherapy

The present study aimed to assess the changes in salivary profile and its clinical correlation in leukemic (ALL) children undergoing chemotherapy. Chemotherapy adversely affects the salivary glands, altering the quality and quantity of saliva. Several chemotherapeutic agents cause damage to the mucosa which affects the dividing cells of Basal epithelium and also, direct contact of these agents with connective tissues can lead to their extensive damage.

Children who have been diagnosed with Acute Lymphoblastic Leukaemia undergoing chemotherapy in Bharati Hospital, Pune were included in the study. Those children were included who fulfilled the following inclusion and exclusion criteria. Stimulated salivary samples were collected in sterile vials at 1-, 3-, and 6-month intervals and were assessed for salivary pH and buffering capacity. Caries and oral manifestations were also checked at each interval. A total of 25 children with ALL undergoing chemotherapy were included to participate in the study. The results were analysed using Statistical Package for the Social Sciences software. All the major changes were seen in the 1st month, that is, the induction phase of chemotherapy. Hence, we can say this is the most affected phase of chemotherapy. Mucositis was more common in the prepubertal age group than the younger age group in the present study. Also, it was more common in girls than boys. Given that parents and kids should be motivated to practice good dental hygiene, this study has clinical significance. To prevent difficulties later on, all preventive dental procedures should be completed as soon as feasible before starting chemotherapy.