Allergic Rhinitis and Laryngeal Pathology: Real-World Evidence

Wang, Yun-Ting and Chang, Geng-He and Yang, Yao-Hsu and Liu, Chia-Yen and Tsai, Yao-Te and Hsu, Cheng-Ming and Lee, Yi-Chan and Lee, Li-Ang and Yang, Pei-Rung and Tsai, Ming-Shao and Li, Hsueh-Yu (2021) Allergic Rhinitis and Laryngeal Pathology: Real-World Evidence. Healthcare, 9 (1). p. 36. ISSN 2227-9032

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Abstract

Allergic rhinitis (AR) is correlated with diseases including allergic laryngitis, chronic obstructive pulmonary disease (COPD), asthma, and chronic rhinosinusitis (CRS). The unified airway model suggests that inflammation can spread in both lower and upper respiratory tracts. Moreover, some voice problems—laryngeal edema, dysphonia, and vocal nodules—have been associated with AR. We examined the association between AR and laryngeal pathology. We investigated 51,618 patients with AR between 1 January 1997 and 31 December 2013, along with 206,472 patients without AR matched based on age, gender, urbanization level, and socioeconomic status at a 1:4 ratio. We followed patients up to the end of 2013 or their death. The occurrence of laryngeal pathology was the primary outcome. Individuals with AR had a 2.43 times higher risk of laryngeal pathology than the comparison cohort group (adjusted HR: 2.43, 95% CI: 2.36–2.50, p < 0.001). Patients diagnosed as having AR exhibited higher comorbidity rates, including of asthma, COPD, CRS, gastroesophageal reflux disease, and nasal septum deviation, than those of the comparison cohort. Our results strongly indicate that AR is an independent risk factor for laryngeal pathology. Therefore, when treating AR and voice problems, physicians should be attuned to possible laryngeal pathology.

Item Type: Article
Subjects: European Repository > Medical Science
Depositing User: Managing Editor
Date Deposited: 13 Mar 2023 04:27
Last Modified: 17 Apr 2024 13:23
URI: http://go7publish.com/id/eprint/509

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