The Influence of Differences in Solvents and Concentration on the Efficacy of Propofol at Induction of Anesthesia

Obata, Yukako and Adachi, Yushi U. and Suzuki, Katsumi and Itagaki, Taiga and Kato, Hiromi and Satomoto, Maiko and Nakajima, Yoshiki (2016) The Influence of Differences in Solvents and Concentration on the Efficacy of Propofol at Induction of Anesthesia. Anesthesiology Research and Practice, 2016. pp. 1-4. ISSN 1687-6962

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Abstract

Background. Propofol is a popular intravenous anesthetic and varieties of formulations were produced from different laboratories. The present study compared efficacy of propofol of different laboratories and different concentrations (1 and 2%) during induction of anesthesia. Methods. Seventy-five scheduled surgical patients were randomly allocated into three groups. The patients of group D1 received AstraZeneca Diprivan 1% (Osaka, Japan) at a rate of 40 mg kg−1 h−1. Group M1 was given 1% Maruishi (Maruishi Pharmaceutical, Osaka, Japan) and group M2 was given 2% formulation at the same rate of propofol. Achieving hypnosis was defined as failure to open their eyes in response to a verbal command and the venous blood sample was withdrawn. Results. The hypnotic doses of M2 were significantly larger (D1: , M1: , and M2:  mg, resp. (mean ± SD). ). Age and gender were selected as statistically significant covariates using general linear model-ANOVA. The blood concentration showed no significant difference among the groups (, , and  μg mL−1, resp.). Conclusion. The required dose of propofol was different among the formulations; however, the serum concentration showed no significant difference.

Item Type: Article
Subjects: European Repository > Medical Science
Depositing User: Managing Editor
Date Deposited: 25 Mar 2023 06:26
Last Modified: 02 May 2024 08:30
URI: http://go7publish.com/id/eprint/858

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