Massive Acute Hemolysis in Two Siblings with Glucose Dehydrogenase Deficiency and Parvovirus B19 Infection

Yokoyama, Koji and Yoshida, Akira (2022) Massive Acute Hemolysis in Two Siblings with Glucose Dehydrogenase Deficiency and Parvovirus B19 Infection. International Journal of Medical and Pharmaceutical Case Reports, 15 (2). pp. 9-11. ISSN 2394-109X

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Official URL: https://doi.org/10.9734/ijmpcr/2022/v15i230152

Abstract

Aims: A previous study reported hemolytic crisis in patients with erythro-enzymopathy. Here, we report two further cases of massive acute hemolysis with methemoglobinemia in two siblings with glucose dehydrogenase deficiency and parvovirus B19 (PAVB) infection.

Presentations of Case: The first was his 8-year-old brother, who developed mild hemolysis with liver dysfunction and survived. The second patient was a 10-year-old boy, who developed liver and kidney failure and died. To elucidate the mechanisms through which PAVB can cause liver and kidney failure, we analyzed cytokines and virus burden.

Conclusion: Physicians should be aware that severe hemolysis may occur in patients with hematological abnormalities and PAVB infection.

Item Type:	Article
Subjects:	European Repository > Medical Science
Depositing User:	Managing Editor
Date Deposited:	27 Jan 2023 12:37
Last Modified:	06 Mar 2024 03:53
URI:	http://go7publish.com/id/eprint/938

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