Effect of H. pylori among Diabetic Patients Living in Khartoum State, Sudan

Background: Studies suggest an association between Helicobacter pylori (H. pylori) infection and extra gastrointestinal disease. Limited studies provided conflicting results on the association between H. pylori infection and diabetes. The present study was aimed at examining the association between H. pylori infection and diabetes among Sudanese patients.

Methods: This was case control study conducted among Sudanese diabetic patients during the period from May 2018 to July 2021. A total of 181 diabetics patients are involved in this study. Blood, stool samples were collected from each participant. All stool samples were tested for the presence of H. pylori antigen by using commercially available H. pylori antigen detection card. Based on the result examination for H. pylori the study population are sub grouped in two groups one group 124 of cases with Positive H. pylori antigen and another group 57 of controls with negative H. pylori infection. Both groups were assessed for the level of fasting blood glucose. Data was gathered and analyzed by using SPSS version 20.

Results: among cases group the mean of fasting blood glucose was 201.94± 90.45 mg/dl compared to 199.40± 97.83 mg/dl among control group. The statistical analysis was showed insignificant difference between cases and controls in the level of fasting blood glucose with P-value of 0.864 . In addition, among cases group the mean of male’s blood glucose 213.0±91.52 mg/dl was higher than females blood glucose level 185.0 ±87.0 mg/dl.

Conclusion: They were insignificant association between blood glucose level and H. pylori infection among diabetes patents, However, the subgroup analysis suggested that H. pylori infection was possibly associated with increased risk of diabetes among males. Future cohort studies are needed to verify this association in females and to address possible implication in the prevention of diabetes.